ecancermedicalscience

Review

Anti-androgenic effects of flavonols in prostate cancer

22 Oct 2015
Tristan Boam

Dietary-derived agents, such as the flavonoids, are of particular interest for prostate cancer (PCa) chemoprevention as they may offer a favourable safety and side-effect profile. An agent that demonstrates action on the androgen receptor (AR) axis may have value for preventing or treating castrate-resistant PCa. Four main flavonols – quercetin, myricetin, kaempferol, and fisetin – have been demonstrated in laboratory studies to have chemopreventive action in both castrate-resistant and castrate-sensitive PCa models. Mechanisms of flavonol action on the AR axis in PCa have been proposed to be inhibition of the 5α-reductase enzymes, direct androgen competition, suppression of the AR complex and transactivation by coregulators such as c-Jun, Sp1, and the PI3K/Akt pathway. It is, however, still unclear with current levels of evidence whether AR axis-mediated effects can fully account for the flavonols’ chemopreventive action.

Related Articles

Panzardi Nicolás, Fernández-Alberti Joaquin, Schinoni Juan Pablo, Ares Jorge Hugo, Iotti Alejandro, Featherston Marcelo
Manuel Bazan, Claudia Gutiérrez-Villamil, Amalia Peix, Saurabh Malhotra, Fernando Dettori, Roberto N Agüero, Belén Flores, Claudio Tinoco Mesquita, Enrique Hiplan, Teresa Massardo, Isabel Berrocal, José A Coss, Verónica Gómez, María C Fonseca, Karla Abadí, Adriana Puente, Víctor Rosales, Luis F Chen, Yariela Herrera, Marina Arnal, Aurelio Mendoza, Omar Alonso, Jorge E Aguiar, Carla Cueva, Enrique Estrada, Diana Páez
Sudarshan Govender, Tamsin K Phillips, Fiona M Walter, Sarah Day, Bothwell Guzha, Suzanne E Scott, Zvavahera M Chirenje, John E Ataguba, Nomonde Mbatani, Nazia Fakie, Jennifer Moodley
Abbas A Abdus-salam, Chiamaka G Ehiedu, Olabisi T Ojo, Atara I Ntekim, Mutiu A Jimoh, Mariam A Bashir, Daluchukwu J Obi, Abel S Anegbe