Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer

22 Apr 2015

Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

2065-barriers-and-facilitators-of-adoption-and-implementation-of-a-financial-navigation-program-cost-fin-trial

Research: Barriers and facilitators of adoption and implementation of a financial navigation program: cost-fin trial

Adewale Isaiah Oyewole, Funmilola Olanike Wuraola, Amir H Sohail, Titilope Ogunniyi, Chinyere Nwankwo, Zainab Oyindamola Adegbite, Dorcas Olaide Ebekue, Clement D Awe, Elizabeth N Christian, Kristina Diaz, Oluwasegun Afolaranmi, Clara N Lambert, Dan Sherman, George Gutierrez, Chinenye Iwuji, Juliet S Lumati

22 Jan 2026

https://doi.org/10.3332/ecancer.2026.2065

Abstract | Full Article | PDF

2066-real-world-evaluation-of-bevacizumab-plus-platinum-and-paclitaxel-for-advanced-cervical-cancer-a-single-arm-study-from-syria

Clinical Study: Real-world evaluation of bevacizumab plus platinum and paclitaxel for advanced cervical cancer: a single-arm study from Syria

Bana Mohamad, Maher Saifo

22 Jan 2026

https://doi.org/10.3332/ecancer.2026.2066

Abstract | Full Article | PDF

2067-a-report-from-the-second-tanzania-liver-cancer-conference-tlcc-2025-leading-the-fight-against-liver-cancer-in-sub-saharan-africa

Conference Report: A report from the Second Tanzania Liver Cancer Conference (TLCC) 2025 – leading the fight against liver cancer in Sub-Saharan Africa

Ally H Mwanga, Jeanine Justiniano, Eric M Mbuguje, Balowa Musa, Deogratius B Mwanakulya, Andrew Swallow, Edith Kimambo, Eva Uiso, Swaleh Pazi, Latifa Rajab, Nashivai E Kivuyo, Larry Akoko, Azza Naif, Advera Ngaiza, Sara Nyagabona, Jerry Ndumbalo, Amos R Mwakigonja, Jim E Littlejohn, Seif Wibonela, Cameron E Gaskill

22 Jan 2026

https://doi.org/10.3332/ecancer.2026.2067

Abstract | Full Article | PDF

2059-oncology-with-common-sense-beyond-biologistic-and-pharmacological-models

Policy: Oncology with common sense: beyond biologistic and pharmacological models

Rodrigo Lastra, Patricia Iranzo, Javier-David Benítez-Fuentes, Ana Callejo, Mara Cruellas, Jacobo Gómez Ulla, Isabel Pimentel, José Luis Pérez-Gracia, Marta Ramos, Francisco Gil Moncayo, María Álvarez Alejandro, Marta Gascón, Sergio Martínez Recio, Pilar Rivero, Jorge Bartolomé, Antonio David Lázaro Sánchez, David Fernández Garay, Alicia de Luna Aguilar, Isabel Lorenzo Lorenzo, Joan Brunet, Noemi Reguart, Dario Trapani

16 Jan 2026

https://doi.org/10.3332/ecancer.2026.2059

Abstract | Full Article | PDF