The National Paediatric Psycho Oncology Conference 2025 was the first such conference to be conducted in India with an exclusive focus on paediatric psycho-oncology. The conference brought together a multidisciplinary faculty coupled with participants from various specialities, including paediatric oncologists, surgical oncologists, radiation oncologists, nutritionists, nurses, psychologists, psychiatrists, social workers and trained psycho oncologists. This 2-day programme began with a hands-on skill-building workshop, followed by a day full of evidence-based, clinically applicable and research-rooted topics and discussions specific to various aspects of paediatric psycho-oncology. The added objective of focusing on applicability in low- and middle-income settings, while keeping cultural relevance in mindaided in making the discussions specific to the Indian context.