Radical en bloc peritonectomy in advanced ovarian cancer
Víctor Lago1,2, Santiago Domingo1, Luis Matute1, Pablo Padilla-Iserte1 and Marta Gurrea1
1Department of Gynecologic Oncology, University Hospital La Fe, Valencia 46026, Spain
2orcid.org/0000-0002-2971-1899
Correspondence to: Victor Lago. Email: victor.lago.leal@hotmail.com
Abstract
In order to reach cytoreduction in advanced ovarian cancer, peritonectomy and diaphragmatic stripping are procedures required to remove the disease in the upper abdomen. Diaphragm involvement is estimated in up to 40% of cases. Nevertheless, in some of these patients, the tumour volume may constitute a limitation of the technique due to the association with abdominal wall involvement, bulky tumour at the Morrison’s pouch or liver infiltration. Extensive upper abdominal procedures should represent a basic resource for the gynaecologic oncologist in order to reach an optimal cytoreduction. A radical peritonectomy with en bloc resection for treating advanced ovarian cancer with extensive widespread diaphragmatic peritoneal carcinomatosis is showed in this surgical film.
Keywords: advanced ovarian cancer, debulking surgery, radical peritonectomy
Copyright: © the authors; licensee ecancermedicalscience. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Published: 08/02/2018; Received: 13/11/2017
Objective
In patients with advanced ovarian cancer, peritoneal carcinomatosis is commonly reported. Peritonectomy and diaphragmatic stripping are the elective procedures chosen to remove the disease in the upper abdomen at the diaphragm [1]. Nevertheless, in some cases the tumour volume may represent a limitation of the technique due to abdominal wall involvement, bulky tumour at the Morrison’s pouch or liver infiltration [2]. A radical peritonectomy with en bloc resection for treating advanced ovarian cancer with peritoneal carcinomatosis involving abdominal wall, liver and bulky tumour at Morrison’s pouch is shown in a surgical film (Video 1).
Methods
A patient diagnosed with a high-grade serous carcinoma of the ovary is presented. Computed tomography demonstrated subdiaphragmatic implants, omental cake, and bilateral pelvic mass infiltrating the uterus, adnexa, cul-de-sac and pelvic peritoneum. Primary debulking surgery was considered after laparoscopic assessment. Peritoneal carcinomatosis infiltrating abdominal wall and liver was found. Bulky tumour at Morrison’s pouch was also present. A radical peritonectomy with en bloc resection of the described locations was performed.
Results
After modified posterior pelvic exenteration, cholecystectomy, splenectomy and radical omentectomy were performed, the upper abdomen was adequately exposed. From beyond the upper limb, parietal peritoneum was dissected from the subdiaphragmatic, paracolic areas and Morrison’s pouch. The tumour present at the right abdominal wall and liver parenchyma was resected en bloc with the parietal peritoneum (Video 1).
Discussion
At the upper abdomen, tumour is commonly present in advanced ovarian cancer. Diaphragm involvement is estimated in about 40% of the patients with advanced ovarian cancer [3]. Diaphragm peritonectomy procedure is related with an acceptable morbidity rate [4]. As a result, extensive upper abdominal techniques should represent a basic resource of the gynaecologic oncologist to achieve an optimal cytoreduction.
Video 1. A radical peritonectomy procedure is shown in this video, in which a tumour present at diaphragm peritoneum, abdominal wall and liver parenchima was en bloc resected.
Conclusions
Radical peritonectomy with en bloc abdominal wall and liver resection is a feasible procedure for removing metastasis in advanced ovarian cancer patients in order to reach an optimal cytoreduction.
References
1. Aletti GD, Dowdy SC, and Podratz KC, et al (2006) Surgical treatment of diaphragm disease correlates with improved survival in optimally debulked advanced stage ovarian cancer Gynecol Oncol 100 283–287 https://doi.org/10.1016/j.ygyno.2005.08.027
2. Shih KK and Chi DS (2010) Maximal cytoreductive effort in epithelial ovarian cancer surgery J Gynecol Oncol 21 75–80 https://doi.org/10.3802/jgo.2010.21.2.75 PMID: 20613895 PMCID: 2895720
3. Bogani G, Ditto A, and Martinelli F, et al (2016) Surgical techniques for diaphragmatic resection during cytoreduction in advanced or recurrent ovarian carcinoma: a systematic Review and meta-analysis Int J Gynecol Cancer 26(2) 371–380 https://doi.org/10.1097/IGC.0000000000000597
4. Ye S, He T, and Liang S, et al (2017) Diaphragmatic surgery and related complications in primary cytoreduction for advanced ovarian, tubal, and peritoneal carcinoma BMC Cancer 17 317 https://doi.org/10.1186/s12885-017-3311-8 PMID: 28476108 PMCID: 5420098
