ecancermedicalscience

Research

A comparison of dosimetric parameters in high-dose-rate intracavitary brachytherapy using tandem and ring applicators: is the combination of a rectal retractor and radio-opaque vaginal packing better than rectal retractor alone for rectum sparing in cervical cancer?

8 Aug 2022
Siddarth Vats, Shabnum Thakur, Mukesh Sharma, Manish Gupta, Lalit Chandrakant, Muninder Negi, Swati Verma, Anup Negi, Vivek Kumar, Parul Sharma, Rattan Mahesh Negi

Purpose: To describe a novel packing technique of combining radio-opaque vaginal packing (VP) with rectal retractor (RR) blade to displace rectum and to compare the standard International Commission on Radiation Units & Measurements-38 (ICRU-38) rectal, bladder point doses and volume parameters with the conventional technique of using RR alone with tandem and ring (T&R) applicators in high-dose-rate (HDR) intracavitary brachytherapy (ICB) for cervical cancer.

Materials and methods: A retrospective analysis of the treatment plans of a cohort of 24 consecutively treated patients with locally advanced cervical cancer was performed. All patients received external beam radiotherapy with a dose of 45–50.4 Gy, in fractions of 1.8–2 Gy, to the whole pelvis with concurrent weekly chemotherapy, followed by HDR-ICB. The treatment plans for each brachytherapy session using T&R applicators that these patients received were included for analysis. A total of 17 treatment plans in which the combination of RR and radio-opaque VP was used for rectum separation were included in the combination (RR+VP) group, and 21 treatment plans in which a RR alone was used were included in the conventional (RR) group.

Results: The mean dose to the ICRU rectal point was 39.7% of the point A dose (range, 28.8%–50.4%; median 38.6%) in the RR+VP group and 52.7% (range, 46.9%–63.6%; median 51.7%) in the RR group. This 13% reduction in the mean dose to the ICRU rectal point was statistically significant (p = 0.001). The mean dose to the ICRU bladder point was 55.4% of the point A dose (range, 26.3%–73.6%; median 57.4%) in the RR+VP group and 45.3% (range, 23.7%–72.7%; median 46.9%) in the RR group. This 10.1% increase in the mean dose to the ICRU bladder point was also significant (p = 0.024). The other point dose and volume parameters were similar between groups.

Conclusion: Compared to the conventional use of a RR blade alone for rectum separation, combining a RR blade with radio-opaque VP significantly reduced the ICRU rectal point dose.

Related Articles

Judith Naa Odey Tackie, Ernestina Schandorf, Patrick Bankah, Hafisatu Gbadamosi, Joseph Daniels, Mary Ann Dadzie
Oluwaseyi K Idowu, Adewumi O Alabi, Ibijoke A Idowu, Opeyemi I Olusunmade, Bright A Igbinoba, Abdulwahab Ajani, Mohammed Y M Habeebu, Jane U Igwilo, Kolawole O Aramide, Eyitayo O Alabi, Fatimah B Abdulkareem, Samuel U Eyesan, Suleiman O Giwa
Godwin Uwagba, Adedayo Joseph, Muhammed Habeebu, Eben Aje, Aishat Oladipo, Olufunmilayo Fagbemide, Precious Akowe, Azeezat Ajose, Adebayo Abe, Samuel Adeneye, Ibrahim Elhamamsi, Abdallah Kotkat, Nusirat Adedewe, Inioluwa Ariyo, Wonuola Adetugbogbo, Francis Durosinmi-Etti
Natalia Camejo, Camila Montenegro, Dahiana Amarillo, Cecilia Castillo, Gabriel Krygier