Dr Sudeep Gupta ( Tata memorial hospital, Mumbai, India), Dr Vijay Patel ( Tata memorial hospital, Mumbai, India), Dr Supriya Chopra ( Tata memorial hospital, Mumbai, India), Dr Joyita Deodhar ( Tata memorial hospital, Mumbai, India), Dr Gouri Pantvaidya ( Tata memorial hospital, Mumbai, India) and Dr Nikita Mehra (Cancer Institute, India) discuss the challenges and opportunities in conducting clinical trials in India. They enlist some of the problems faced whilst conducting trials and the areas in which expansion and improvement can be done.