A novel strategy in treating endocrine resistance using combination therapy

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Published: 28 Jan 2010
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Dr Rajeshwar Rao Tekmal - University of Texas Health Science Center, San Antonio, USA
Treating oestrogen receptor-positive breast cancer tumours with a combination of fidarestat (an inhibitor of aldose reductase enzyme) and letrozole (an aromatase inhibitor) could delay or stop tumour resistance to endocrine therapy. Single agents are less effective. Many tumors develop resistance, so this combination approach could prolong that window when endocrine therapy is effective. Official San Antonio Breast Cancer Symposium press conference.