Adding nivolumab to R-GemOx shows enhanced efficacy in treating R/R large B-cell lymphoma

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Published: 20 Dec 2023
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Dr Gerhard Held - Westpfalz-Klinikum, Kaiserslautern, Germany

Dr Gerhard Held speaks to ecancer about the interim analysis of the Niveau trial which is an international, randomised phase 3 study of the AGMT, GLA, HOVON, Lysa and PLRG.

The objective of this study was to evaluate the efficacy and safety of nivolumab added to R-GemOx in patients with R/R LBCL after 1 prior line of therapy not eligible for HDCT/HSCT owing to age and/or comorbidities.

The study found that the addition of nivolumab to R-GemOx and subsequent maintenance with nivolumab did not improve progression-free survival. However, there was a trend towards improved overall survival, suggesting that nivolumab may enhance the efficacy of subsequent therapies.

The study is ongoing with a final analysis scheduled after completion of follow-up.