ecancermedicalscience

Case Report

Cisplatin induced cerebral sinus venous thrombosis in cervical cancer patients treated with concurrent chemoradiation: a case series

18 Nov 2021
Deepthi Valiyaveettil, Swapna Jilla, Jonnalagadda Mohan Krishna, Raja Kollu, Chandrasekhar Patil, Ranadheer Gupta

Cisplatin is a widely used chemotherapeutic agent. Concurrent chemotherapy with cisplatin is an important component in the management of carcinoma cervix. The common side effects of cisplatin chemotherapy include nausea, vomiting, dyselectrolytemia, nephrotoxicity, etc. These side effects are anticipated and managed during chemotherapy. Thromboembolic events are rare complications with cisplatin. We present three cases of cisplatin related cerebral sinus venous thrombosis (CSVT). These patients were receiving concurrent chemoradiation for carcinoma cervix. These patients presented with neurological symptoms and were evaluated and diagnosed with CSVT. They recovered after appropriate management. Clinicians should be aware that CSVT, though uncommon, is a life threatening complication during cisplatin chemotherapy which should be appropriately evaluated and effectively managed.

Related Articles

Lucas Tadeu Barrak Stangler, Amanda Acioli de Almeida Robatto, Pedro José Galvão Freire, Gilberto de Castro Junior
Sidhart Misra, Zainab Yusufali Motiwala, Ayyaz Mulla, Jagatheswaran Chinnathambi, Danny Darlington Carbin
Muhammad Arif Hameed, Yasmin Abdul Rashid, Insia Ali, Waqas Ahmed Khan, Tasneem Dawood, Misbah Soomro, Mirza Rameez Samar