The first annual CCSB workshop brings together clinicians, biologists, mathematicians, and computer scientists to discuss various aspects of tumor dormancy. Specific topics include the angiogenic switch, immune system interactions, cancer stem cells and signaling. Each workshop topic will be discussed in morning keynote lectures by a clinician, a biologist, and a mathematician. Breakout working groups will be held in the afternoon, where workshop participants will discuss current problems related to tumor dormancy with the keynote speakers and develop novel mathematical/computational models. This workshop is part of the Center of Cancer Systems Biology (CCSB) outreach and education effort funded by the National Cancer Institute's Integrative Cancer Biology Program (ICBP). The CCSB based at St. Elizabeth's Medical Center, Tufts University School of Medicine in Boston, USA brings together diverse researchers to better understand the molecular and tissue-level events underlying the evolution and progression of cancer. The team of lab investigators and research staff assembled at the CCSB is working to develop novel quantitative and qualitative approaches to the problem of cancer, both at the molecular and at the systems level.