The importance of target expression in personalised medicine

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Published: 6 Jul 2015
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Dr Paolo Nuciforo - Vall d'Hebron Institute of Oncology, Barcelona, Spain

Dr Nuciforo talks to ecancertv at WIN 2015 about Vall d'Hebron's work looking for biomarkers, and the importance of looking at genetic expression, as well as alterations, to give better insight into what may lie downstream.

The importance of target expression in personalised medicine

Dr Paolo Nuciforo - Vall d'Hebron Institute of Oncology, Barcelona, Spain


We are involved in developing and validating biomarkers for pre-selecting the patient in clinical studies. We have a particular interest in the quantification of proteins; it’s something that is becoming very appealing and interesting. During this WIN Symposium it emerged that not only the presence of the genetic alteration is critical but also what is downstream and what is the expression of the genes involved in the pathway. This is at RNA level but also at the protein levels and we are studying this at Vall d’Hebron where the idea is to combine genetic information with expression data of the RNA and with the protein.