Molecular pathways associated with immune modulation and thalidomide analogues

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Published: 25 Mar 2014
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Dr Rajesh Chopra - Vice President of Translational and Early Drug Development, Celgene

Dr Chopra talks to ecancertv at the 1st Immunotherapy of Cancer Conference ( ITOC ) in Munich about a newly discovered mechanism of action for immunomodulatory thalidomide analogues.

These act by modulating the way certain proteins are degraded, thus preventing the growth of certain tumours such as lymphoma.

This also negatively affects B-Cell development, but in turn activates T-Cells.

The therapy could be combined with other antibodies and vaccines.