Brain metastases from lung cancer are the most prevalent type with high numbers of patients developing brain metastases each year. Dr Lucio Crinò from University Hospital of Perugia, Italy discusses the recent analysis of Crizotinib data on brain metastases in lung cancer patients. The standard of care for these patients is traditional surgery, chemotherapy, or radiotherapy with Gamma Knife. Dr Crinò looks at the molecular characteristics of the new targeted treatments such as Crizotinib, and the implications for overall survival and quality of life in this patient population.