Prof Richard Bryant speaks to ecancer about local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection.

The TRANSLATE trial is a multicentre, randomised, controlled trial in the UK that compares local anaesthetic transperineal biopsy with traditional transrectal biopsy for detecting significant prostate cancer.

Involving 1,126 participants, the study finds a 5.7% increase in cancer detection with the transperineal method.

While it shows fewer infections, men report more embarrassment and pain. Cost-effectiveness analysis suggests longer procedure times make it less cost-effective, guiding future recommendations.