Dr Melissa Johnson presents the primary analysis of the phase 3 CodeBreaK 200 trial comparing sotorasib versus docetaxel in previously treated KRAS G12C-mutated NSCLC.
In this first, randomised phase 3 trial for a KRAS G12C inhibitor, oral sotorasib demonstrated superior PFS and ORR compared to intravenous docetaxel and had a more favourable safety profile.