The mechanism by which PI3 kinase/mTOR inhibition increases sensitivity of oestrogen receptor (ER)-positive breast cancers to CDK4/6 inhibition is by blocking cell cycle re-entry driven by cyclin D1 and by inducing apoptosis, according to findings presented during a session at the IMPAKT Breast Cancer Conference held 7–9 May 2015 in Brussels, Belgium.

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Source: ESMO