Cyclin-dependent kinases (CDK) 4 and 6 are viable therapeutic target in HER2-positive breast cancer models that functions downstream of HER2.
Tissue based markers are available to direct rational utilisation of selective CDK4/6 inhibitor palbociclib, according to the study performed in a combination of cell culture, mouse models and human primary tumour explants.
The results were presented by Dr Erik Knudsen of the University of Texas Southwestern, Dallas, USA.
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Source: ESMO
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