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ASTRO 2025: Health-related quality of life analysis shows benefit in both proton and photon radiation options in breast cancer patients

1 Oct 2025
ASTRO 2025: Health-related quality of life analysis shows benefit in both proton and photon radiation options in breast cancer patients

Results from the health-related quality of life (HRQOL) analysis of the University of Pennsylvania and RTOG Foundation RadComp study indicated that both photon and proton radiation treatment options yielded similar, excellent HRQOL outcomes for women with non-metastatic breast cancer.

RadComp was the first randomised study comparing proton to photon radiation for breast cancer treatment.

These results were recently reported during the Plenary Session of the American Society for Radiation Oncology Annual Meeting in San Francisco, California.

“The successful completion of RadComp, the largest randomised trial comparing photon and proton therapy, is a testament to the field's commitment to comparing technologies.  HRQOL is an essential endpoint, and the excellent outcomes for both arms are encouraging. While we await our primary endpoint, physicians should continue to select the appropriate modality of treatment for patients with breast cancer, taking into consideration patient- and disease-specific factors as well as regional access and cost,” stated Shannon M.

MacDonald, MD, of the Southwest Florida Proton Centre and the lead author of the RADCOMP manuscript.

The RadComp trial accrued 1,239 patients with non-metastatic breast cancer who were planning to undergo comprehensive nodal irradiation and assessed them to compare patient-reported body image and function, fatigue, and other HRQOL outcomes after receiving either proton radiotherapy or photon radiotherapy.

HRQOL was primarily assessed using PROMIS Fatigue, Satisfaction with Breast Cosmetic Outcomes, BREAST-Q adverse effects of radiotherapy, and FACT-B. Other domains, including FACIT-TS-G and PRO-CTCAE, were also used.

At 6 months following treatment, there were no statistically significant differences between treatment arms in the PROMIS Fatigue total score, Satisfaction with Breast Cosmetic Outcomes score, BREAST-Q total score, and FACT-B trial outcome index score.

For the secondary HRQOL tools, there were a few differences in favour of proton therapy in willingness to recommend treatment and to choose treatment again.

According to Drs. Alexander Lin, MD and Bonnie Ky, MD, MSCE, the current Principal Investigators of the study at the Perelman School of Medicine at the University of Pennsylvania, “This trial speaks to the tremendous multi-disciplinary collaboration across radiation oncologists, cardiologists, physicists, scientists, and most importantly, our patients.  We eagerly await the primary endpoint of the RadComp trial, major cardiac events, which we will report in the future, in accordance with the study’s statistical plan.”

Research reported in this work was funded through a Patient-Centred Outcomes Research Institute (PCORI) Award (PCS-1403-12804), National Cancer Institute of the National Institutes of Health (PHR-SS-S-16-004996), National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL152707), and the David and Leslie Clarke Outcomes Research Fund, the Gant Family Foundation Fund, Alan and Louise Reed Cancer Outcomes Research Fund, and the Thalheimer Centre for Cardio-Oncology at the Raymond at Ruth Perelman School of Medicine of the University of Pennsylvania.

Article: RadComp Study Health-Related Quality of Life Analysis Shows Benefit in Both Proton and Photon Radiation Options in Breast Cancer Patients

Source: RTOG Foundation