A pivotal study uncovers the molecular signatures of mammographic calcifications in hormone receptor-positive, HER2-negative breast cancer.

The research identifies distinct molecular traits associated with calcification status, suggesting that tumours with probably benign calcifications are linked to higher hormone receptor expression and endocrine therapy sensitivity, while tumours with calcifications of high suspicion for malignancy show genomic instability and cell cycle activity, pointing towards the effectiveness of CDK4/6 inhibitors.

This molecular stratification may revolutionise precision treatment in breast cancer.

Mammographic calcifications, a common feature of breast cancer, have remained enigmatic in terms of their molecular underpinnings and clinical implications, particularly in the hormone receptor-positive, HER2-negative subtype.

The heterogeneity of these calcifications and their association with treatment outcomes highlight a critical need for a comprehensive investigation into their molecular characteristics.

Understanding this link is essential for developing personalised treatment strategies that have the potential toimprove patient prognosis and survival rates.

Researchers at Fudan University Shanghai Cancer Center have made significant strides in understanding breast cancer calcifications, particularly in hormone receptor-positive, HER2-negative tumours.

Their findings published in Cancer Biology & Medicine, offer new insights into the molecular profiles linked to these calcifications. This study could transform how we approach personalised treatment strategies in breast cancer.

The study examined 316 breast cancer patients, categorising tumours based on calcification status into calcification-negative tumours, tumours withprobably benigncalcifications, tumours with calcification of low-moderate suspicion for malignancy and tumours with calcification of high suspicion for malignancy. tumours with probably benign calcifications showed elevated hormone receptor expression, activation of the estrogen receptor pathway, enhanced lipid metabolism, and increased sensitivity to endocrine therapy.

On the other hand, tumours with calcification ofhigh suspicion for malignancy were associated with larger sizes, higher rates of lymph node metastasis, increased Ki-67 staining, genomic instability, and cell cycle pathway activation.

These findings suggest that patients with highly suspicious calcifications might benefit from CDK4/6 inhibitors. By establishing links between calcification status and molecular characteristics, the research highlights the potential for precision treatment strategies tailored to individual calcification profiles, offering a significant advancement in the management of hormone receptor-positive, HER2-negative breast cancer.

Dr. Ding Ma, a leading researcher in the study, emphasised the transformative potential of these findings: "Our research links mammographic calcifications with specific molecular features, offering a novel pathway to tailored managementsin hormone receptor-positive, HER2-negative breast cancer using readily available clinical imaging data. "

In conclusion, this study connects routine mammographic images with underlying molecular characteristics and treatment strategies, providing new insights into the stratified clinical management of hormone receptor-positive, HER2-negative breast cancer.

Source: Cancer Biology & Medicine