When the PSA is elevated: for which men is a biopsy necessary to confirm or rule out suspected prostate cancer? 

In a retrospective study, scientists from the German Cancer Research Center (DKFZ) and the Department of Urology at Heidelberg University Hospital have shown that the combination of risk markers, systematic evaluation of MRI images and artificial intelligence (AI) can predict the risk of prostate cancer more accurately than before. A biopsy may not be necessary for men at low risk.

Found in the European Journal of Radiology.

If a PSA test shows an elevated value, this may be an indicator of prostate cancer.

To confirm this suspicion, doctors today first order magnetic resonance (MR) imaging as a further diagnostic test.

The "multiparametric MRI" used here combines various imaging techniques and therefore provides very detailed images.

However, final certainty can only be obtained by taking tissue samples from the prostate.

"Biopsies are invasive and in rare cases can lead to infections or bleeding, sometimes even requiring hospitalisation," says David Bonekamp, radiologist at the DKFZ. Doctors are therefore urgently looking for ways to improve risk prediction.

"Our aim is to filter out those men who only have a minimal risk of cancer. They could be spared tissue removal or postpone it for a certain period of time. Men with a high probability of prostate cancer, on the other hand, benefit from the biopsy, as the cancer can be detected early," says Bonekamp.

Today, researchers use a calculator to estimate the risk of prostate cancer, which takes into account various parameters such as PSA value, age and prostate volume as well as the MRI findings.

To this end, doctors use a system known as PI-RADS for the systematised evaluation of MRI images, which ultimately provides a probability value for the presence of prostate cancer.

Could an AI based on deep learning further improve this prediction or possibly even replace PI-RADS?

To test this, Bonekamp's team launched a retrospective study in which they included data from 1627 men who had undergone multi-parametric MRI imaging of the prostate in Heidelberg between 2014 and 2021 and subsequently underwent a biopsy.

An algorithm developed at the DKFZ for evaluating image data was trained with the MRI images of over 1000 of these men.

Using the remaining 500 or so data sets, the researchers tested whether a combination of their risk calculator with the AI could improve the accuracy of prostate cancer prediction.

If the PI-RADS value in the risk calculator was replaced by the AI method, the diagnostic significance hardly changed. In contrast, the combination of AI and PI-RADS delivered significantly better results: It identified 49 percent as minimal risk among men who had originally been biopsied. 

"This means that the combination of deep learning and radiological findings could theoretically have avoided almost half of these biopsies without overlooking a relevant number of tumours," says Adrian Schrader from the DKFZ, first author of the current study.

The radiologists conclude from this result that deep learning-based AI and PI-RADS assessment by experienced radiologists evidently provide complementary diagnostic information, which together contribute to a more precise risk stratification of patients.

"For patients with an elevated PSA value, it could be a great advantage in the future to integrate AI analysis into further diagnostics. However, prospective studies must confirm the benefits of the procedure and clarify that it has no disadvantages for patients," says Bonekamp.

Source: German Cancer Research Center