Scientists have discovered a way to view the immune cell "landscape" of bowel cancer tumours, paving the way towards more individualised medicine and treatment for many other diseases in future.

In a paper published in The Journal of Immunology, scientists have shown the incredible diversity of immune cells that are inside a colorectal tumour.

Immune cells are known to protect against cancer growth and this work provides new information on the types of cells present and how they might be beneficial for the patient.

Lead researcher Associate Professor Roslyn Kemp explained that they are using a new technology called high dimensional mass cytometry to identify cells in the tumours of people with bowel cancer.

"It can be thought of as taking a higher resolution 'photo' of the inside of the tumour. The photo may reveal new types of cells that may or may not be targetable by drugs, or reveal the different composition of immune cell populations in individuals that could be used to predict the course of the disease," said Professor Kemp.

Associate Professor Kemp stated that the results of their study have shown there is huge diversity in the type of immune cells that infiltrate the tumour, which means that any one, or more likely a combination of many immune cells, could have an effect on patient outcomes.

"The technique could be used to study a number of different diseases. It demonstrates the use of a new technology to study the immune response in much more detail than other methods currently used, providing new types of information for patients," Professor Kemp explained.

"It is a step towards personalised medicine, sometimes referred to as precision medicine, since each patient's tumour could be looked at with this amount of detail," Professor Kemp also added.

The next step is to carry out a similar study with a slightly different technique to further investigate where all the cells are in the tumour and how that might affect cell function and relationships between types of cells and patient data like the stage of disease and patient survival.

Source: University of Otago

Photo credit: University of Otago